- Die aktuellen Informationen der WHO finden Sie hier: World Health Organization
- Die Webseite des World Health Summit bietet eine Liste mit Links zu seinem weltweiten Wissenschaftsnetzwerk und der M8 Alliance: World Health Summit
- Die Johns Hopkins University (JHU) ist nicht nur eine zuverlässige Quelle für Infektionszahlen, sie bietet in ihrem Coronavirus Resource Center auch zusätzliche Informationen: Johns Hopkins University
- Die Zusammenstellung zum Coronavirus des JAMA-Netzwerks bietet FAQs sowie Publikationen zu Impfstoffentwicklung, Infektionsbekämpfung und zur Reaktionsfähigkeit des öffentlichen Gesundheitswesens: JAMA Q&A’s & Publications
- The Lancet hat ein Coronavirus Resource Center eingerichtet, das COVID-19-spezifische Artikel aus allen Zeitschriften der Lancet-Gruppe umfasst. Der Zugang ist kostenfrei: Publications Lancet
- Die RSNA Journals haben eine eigene COVID-19-Webseite mit einem besonderen Fokus auf Bildgebung erstellt. Sie enthält Fachartikel, Case Studies, Leitartikel und Podcasts: Publications RSNA
- Das American College of Radiology hat radiologische Materialien zu COVID-19 zusammengestellt: ACR
- Auf ihrer Website hat die European Society for Radiology eine umfangreiche Liste mit Publikationen und Links bereit gestellt: European Society for Radiology
- Ergänzend zur Website hat die ESR auch einen YouTube Kanal mit Vorträgen zu COVID-19 eingerichtet: ESR
- Die Arbeitsgruppe Thoraxdiagnostik der Deutschen Röntgengesellschaft veröffentlicht ihre Empfehlungen: DRG
- Die Society of Nuclear Medicine and Molecular Imaging teilt COVID-19 Strategien und Erfahrungen: SNMMI
- Wiley bietet freien Zugang zum COVID-19 Bereich seiner Online-Bibliothek: Wiley
- Die the American Association for Clinical Chemistry hat zahlreiche Informationen zur Labordiagnostik zusammengestellt: AACC Resources
- Die International Federation of Clinical Chemistry and Laboratory Medicine aktualisiert ihren COVID-19 Leitfaden regelmäßig: IFCC Information Guide on COVID-19
- Mit einem Fokus auf Herzpatienten bietet die American Heart Association hilfreiche Informationen für Kliniken, medizinisches Personal und die Öffentlichkeit: American Heart Association
- Das Emerging Infectious Disease Journal des Centers for Disease Control and Prevention beinhaltet einen speziellen Bereich zu COVID-19: Emerging Infectious Disease
Die folgenden Informationen sind nur auf Englisch verfügbar.
Consensus statement by cardiologists and emergency physicians on managing acute myocardial infarction during COVID-19 in the U.S.
Three U.S. medical societies have published recommendations for a systematic approach to treating AMI patients during the pandemic. The paper builds on the fact that most patients with ischemic heart disease may not have COVID-19, and focuses on topics such as clinical presentations, suitable PPE, and the role of emergency departments and cardiac cath labs.
Study investigating links between fatal COVID-19 outcomes and underlying CVD and myocardial injury
To shed light on the cardiovascular implications of fatal outcomes in COVID-19, researchers conducted a retrospective study at a hospital in Wuhan. They analyzed 187 patients, of whom 27.8% had myocardial injuries. The results provide insights into the links between COVID-19 deaths and CVD and myocardial injury, and offer guidance for triage and treatment.
Immediate and long-term cardiovascular implications of coronaviruses
This Viewpoint article addresses the shortage of published data on cardiovascular presentations in the wake of viral epidemics. The authors examine the acute and long-term cardiovascular implications of respiratory virus infections caused by influenza viruses and coronaviruses, and stress the need for serial follow-up studies of survivors of acute infection.
Report on patient treated with glucocorticoid and human immunoglobulin for coronavirus fulminant myocarditis
Researchers in China report on a man diagnosed with coronavirus fulminant myocarditis with cardiogenic shock and pulmonary infection. Imaging showed significant enlargement of the heart. After treatment, which included methylprednisolone and immunoglobulin, the patient’s symptoms improved markedly and cardiac chamber dimensions quickly returned to normal.
How robotics could potentially reduce exposure to virus patients during interventional procedures in a pandemic
In this interview, Jon George of Einstein Medical Center in Philadelphia, USA, talks about whether robotics could help protect physicians during interventions on virus patients. He explains the benefits of robotics and how it differs from remote PCI. He also discusses his own successful experience of performing robotic PCI in a suspected COVID-19 case.
Interim guidance for healthcare providers caring for pediatric patients with known or suspected COVID-19
European Society of Cardiology publishes dedicated page for COVID-19 resources
ACC Interventional Council and SCAI discuss issues facing catheterization personnel during the COVID-19 pandemic
Statement on continuing ACE-I and ARBs in patients who contract COVID-19
Preparing patients, providers, and health systems for cardiovascular care during COVID-19
Review of literature on cardiovascular considerations for patients, healthcare workers, and health systems during the COVID-19 pandemic
Guidance on managing COVID-19 for resource-limited countries
In this article, the authors give their view on how low- and middle-income countries can prepare for local outbreaks of COVID-19. After reporting on Africa’s preparations for managing the disease, the paper discusses issues such as critical care, minimum requirements for infection prevention and control, refugees, and media support for public health efforts.
Video Q&A with a critical care expert on the front line of the pandemic in New York
Speaking in an interview for JN LearningTM, Michelle N. Gong, Chief of Critical Care Medicine at Montefiore Medical Center in the Bronx, talks to the editor-in-chief of JAMA about planning for the surge in COVID-19 patients. She discusses issues such as managing ARDS, encountering surprising aspects of COVID-19, and procuring diagnostic tests and PPE.
Leading Chinese epidemiologist talks about COVID-19 in China in early 2020
Zunyou Wu, Chief Epidemiologist at the China CDC, joined the editor-in-chief of JAMA in February to review the development and spread of COVID-19 in China. Their conversation covers multiple topics, including confirmed and suspected cases, the challenges of achieving large-scale diagnostic testing, case fatality rates, and asymptomatic spread of the disease.
Leading experts from the University of Washington discuss what they have learned from COVID-19 so far
In this conversation with Diagnostic Imaging, two leading physicians talk about their radiology department’s response to COVID-19. They report on changes in imaging volumes, financial steps taken in light of declining revenues, further planning for the pandemic, and strategies for returning to normal, processing postponed studies, and re-engaging patients.
Free webinar About Italy’s Experience With COVID-19 and Preparing for the Virus
UK Radiologists are Moving to “Clean” and “Covid” CT Scanners
The Key role of Radiology in the COVID-19 Crisis
Emergency management and infection control in a radiology department
Abnormal coagulation results are common in deaths from novel coronavirus pneumonia
The relationship between SARS-CoV-2 infection and coagulation
Common laboratory abnormalities encountered in COVID-19
Description of the epidemiological and clinical characteristics of COVID-19 pneumonia in Wuhan, China, in January 2020
Anticoagulant therapy could reduce mortality in severe COVID-19 patients with coagulopathy
In light of recommendations to treat COVID-19 patients with anticoagulants, researchers performed a retrospective analysis to validate the usefulness of coagulation parameters in identifying patients who could benefit from this therapy. The study found that, in some circumstances, the 28-day mortality of heparin users was lower than that of non-users.
International Society on Thrombosis and Haemostasis provides interim guidance for recognizing and managing coagulopathy in COVID-19
Described as a “pragmatic statement,” this document aims to enable risk stratification at admission and management of coagulopathy using various laboratory parameters. Recommendations include considering hospital admission in cases with markedly raised D-dimer, monitoring coagulation markers to determine prognosis, and managing coagulopathy with heparin.
Empfehlungen der Gesellschaft für Thrombose- und Hämostaseforschung e.V. zur Thromboseprophylaxe bei SARS-CoV-2
Basierend auf der bisher verfügbaren Literatur und in Anlehnung an die International Society on Thrombosis and Haemostasis hat der Vorstand der Gesellschaft für Thrombose- und Hämostaseforschung Empfehlungen zur Prophylaxe von venösen Thromboembolien bei Patienten mit SARS-CoV-2 Infektion (COVID-19) formuliert.
Concise and practical guidance for managing thrombotic risk, coagulopathy, and disseminated intravascular coagulation in COVID-19 patients
This living guidance document will be updated weekly. It discusses current knowledge on the three areas (thrombotic risk, coagulopathy, and DIC) in the context of COVID-19 and outlines practical recommendations for each. These include VTE risk assessment for all patients admitted to hospital, and targeted approaches for managing minor and major bleeding.
A standardized system for assessing pulmonary involvement in COVID-19 using CT images
CO-RADS, developed by the Dutch Radiological Society, is a system that provides a five-point scale for assessing pulmonary involvement in patients with moderate to severe COVID-19 symptoms. The article describes the system and reports on an initial study that evaluated the interobserver variability and diagnostic accuracy of CO-RADS using 105 chest CT scans.
Unexpected findings of COVID-19 identified at lung bases in abdominal CT scans
This paper reports on a retrospective review of abdominal CT images in 23 patients within a single, multicenter institution. Although the patients were not clinically suspected of having COVID-19, the images provided unanticipated findings at the lung bases that raised concern for COVID-19. Most of the patients subsequently tested positive the disease.
Is low-dose submillisievert chest CT imaging suitable for assessing ER patients for COVID-19?
RT-PCR is the gold standard for diagnosing COVID-19, but it is not without drawbacks. Chest CT could be an additional tool for assessing patients. Researchers in Belgium investigated whether low-dose chest CT imaging can rapidly, accurately, and reproducibly stratify ER patients with possible COVID-19.
Retrospective analysis from early 2020 compares chest CT and RT-PCR for sensitivity to COVID-19
This Chinese study involved 51 COVID-19 patients who all had non-contrast chest CT scans and RT-PCR within three days or less. Chest CT imaging was found to have a higher sensitivity than RT-PCR. The authors stress that their results support the use of chest CT for screening patients who have clinical and epidemiological features consistent with COVID-19.
Low-dose protocols to protect patients undergoing CT scans for detecting and managing COVID-19
This editorial notes that, under Chinese guidelines, COVID-19 patients might undergo several CT scans in a short space of time. Since the patient population includes those for whom radiation dose is a particular concern, the authors suggest using low-dose protocols. Their experience provides the framework for the recommendations.
Using well-aerated lung on baseline CT to predict adverse outcomes in COVID-19 pneumonia
To describe the relationship between well-aerated lung on chest CT and COVID-19 prognosis, researchers performed a retrospective study of chest CT scans performed at ER admission. The images were visually scored by radiologists and evaluated using software. Quantifications of lung abnormality were predictors of ICU admission or death in COVID-19.
Feasibility of a low-dose, long-pitch, dual-source chest CT protocol for COVID-19 patients
Assessing the characteristics and clinical value of chest CT images in COVID-19 pneumonia
Study in Xiaogan area of Hubei province reports on imaging manifestations and diagnostic value of chest CT in COVID-19
CT and MRI features of COVID-19–associated acute hemorrhagic necrotizing encephalopathy
Timely diagnosis and treatment accelerates resolution of COVID-19 pneumonia and lowers the highest and last CT scores from sequential chest CT
Thoughts on the conundrum of using CT imaging as a diagnostic tool in COVID-19
High-resolution computed tomography findings in COVID-19 patients of different ages
Longitudinal study of temporal changes in CT findings yields useful data about pattern of COVID-19 pneumonia
Researchers in Wuhan analyzed serial CT findings over time in 90 patients with COVID-19 pneumonia. Key findings relate to progression and peak of abnormalities, predominant patterns of abnormalities, and rates of residual disease. The temporal changes in CT manifestations followed a specific pattern, which could indicate illness progression and recovery.
Evolution of CT manifestations in five patients who recovered from COVID-19 pneumonia
Chest CT images of COVID-19 patients from Diamond Princess cruise ship show changes in asymptomatic cases
Study on transmission routes and extent of contamination by SARS-CoV-2 from a symptomatic patient
This research letter describes a study conducted with three COVID-19 patients in airborne infection rooms. Surface environmental samples were taken from multiple sites, samples of PPE were collected from physicians, and air samples were taken from the rooms and anterooms. Overall, the findings suggest the environment is a potential medium of transmission.
Review of the literature about the persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents
This paper was published online on February 6. Its analysis of 22 studies found that human coronaviruses can persist on surfaces such as metal, glass, or plastic for up to nine days. The authors also found that surface disinfection with specific agents could inactivate the viruses within one minute. They expect this to also apply in the case of SARS-CoV-2.
Strategies used by a Wuhan hospital to protect radiologic technologists against COVID-19
With chest CT playing a key role in diagnosing COVID-19, technologists are at high risk of direct or indirect virus exposure. The authors of this article describe their strategies for protecting technologists in the radiology department of a hospital in Wuhan. The strategies concern staffing arrangements, environmental modifications, CT workflows, and PPE.
FAQs about preventing and controlling COVID-19 infection in healthcare settings
Researchers compare aerosol and surface stability of SARS-CoV-2 and SARS-CoV-1
Inflammation/Plasma Protein Testing
SAA identified as a potential biomarker for clinical severity of COVID-19
To provide knowledge about underlying immunity and early biomarkers in COVID-19, researchers performed a retrospective study of patients diagnosed with the disease at a hospital in China. Dynamic observations of the patients’ serum biochemistry profiles and chest CT imaging indicated that SAA could be a predictor for severe cases of the disease.
Cytokine storm syndromes and immunosuppression in COVID-19
This letter to the Lancet addresses the increasing evidence that suggests some patients with severe COVID-19 might have a cytokine storm syndrome. Given the need to reduce rising mortality, the authors recommend screening patients for hyperinflammation and treating the relevant subgroup with existing, approved therapies that have a proven safety profile.
Retrospective multicenter study indicates predictors of fatal outcomes in COVID-19
To help prioritize resources for high-risk COVID-19 patients, these researchers identified clinical predictors of severe patient outcomes. Using data from death cases and discharged cases, they found that predictors of death include age, underlying diseases, and elevated inflammatory indicators. They also note that cytokine storm syndrome may lead to death.
How immune-suppressive and immune-stimulating drugs affect host immunity against COVID-19
Cancer and transplant patients with COVID-19 are at high risk of severe or fatal outcomes, especially as they might also be receiving drugs to suppress or stimulate their immune systems. This article examines the effects of these drugs on host immunity. The aim is to help physicians identify which drugs could be harmful, and which might be of benefit.
Clinical and biochemical indexes linked to viral loads and lung injury in COVID-19
The authors report on various characteristics and potential biomarkers of disease severity in COVID-19. In their study, laboratory abnormalities mainly included hypoalbuminemia, lymphopenia, and a decreased percentage of lymphocytes and neutrophils. They also found a positive link between viral load in the respiratory tract and lung-disease severity.
A systematic review and meta-analysis of the clinical, laboratory, and imaging features of COVID-19
Early study on the clinical features of COVID-19 in patients in Wuhan, China
Retrospective cohort study on the clinical course of COVID-19 and risk factors for mortality among adult inpatients in Wuhan, China
Clinical characteristics and allergy status of patients infected with SARS-CoV-2 in Wuhan, China
Establishing the role of clinical laboratory data in the differential diagnosis of severe forms of COVID-19
Laboratory medicine has a critical role to play during viral outbreaks such as COVID-19
Hematologic parameters of COVID-19 patients in Singapore in February 2020
Lymphopenia can help predict the prognosis of COVID-19 patients
Opinion paper on potential preanalytical and analytical vulnerabilities in RT-PCR for diagnosing COVID-19
A summary of the unique epidemiological and clinical features of COVID-19 pneumonia, and special control measures for COVID-19
Magnetic Resonance Imaging
Assessing respirators and facemasks for use in MRI during COVID-19
Given that some COVID-19 patients could require MRI exams for comorbidities, researchers assessed four respirators and one facemask for ferromagnetic properties. The study, which involved no patients, found that some respirators were unsuitable for MRI use – due to MRI safety reasons and because torque broke the seal between the mask and the user.
Guidance from the American College of Radiology on COVID-19 and use of MR
These recommendations call on practitioners to only use MR when absolutely necessary, and to postpone all non-urgent exams. They also suggest using alternative imaging methods if appropriate. Other topics addressed include MR room cleaning, use of MR-safe facemasks or respirators for patients, and considerations regarding PPE worn by MR technologists.
First report on using MRI to evaluate patients with anosmia induced by SARS-CoV-2 in Iran
Micropractices recommended for preventing burnout and improving emotional wellness in medical professionals
Assessing mental health outcomes and associated factors among healthcare workers treating patients exposed to COVID-19 in China
Helping nuclear medicine departments function in the COVID-19 pandemic
These guidelines were informed by a systematic review of the literature and input from international experts during an IAEA webinar. The aim is to help nuclear medicine facilities adjust and adapt to the current situation. The authors address six main processes, based on WHO guidance, for maintaining nuclear medicine operations during the pandemic.
Nuclear medicine departments in different countries report on their COVID-19 strategies, precautions, and experiences
First 18F-FDG PET/CT findings in patients with highly suspected COVID-19
Nuclear medicine examinations might lead to incidental findings suggestive of COVID-19 in asymptomatic patients
Key considerations for COVID-19 policies and processes in a nuclear medicine service, based on experience from Singapore
FDG PET/CT could offer added value for patients with COVID-19 pneumonia
European experts publish position paper on managing liver disease during the COVID-19 pandemic
These recommendations, published by the EASL and ESCMID, focus on caring for patients with chronic liver disease and for those who have received a liver transplant. They address specific characteristics of patients with liver disease, and discuss topics such as outpatient care, methods for reducing direct exposure, and liver-related diagnostic procedures.
Leaders in breast imaging in the U.S. discuss their response to COVID-19
Preliminary report of lung ultrasound characteristics in children with COVID-19 in Italy
Researchers in Turin investigated lung ultrasound findings in children with SARS-CoV-2 infection. The modality offers many benefits (such as reducing patient movement around the hospital and minimizing radiation exposure) that are relevant for COVID-19 and children. The observational study found a high concordance between radiologic and ultrasound findings.
A concise overview of laboratory abnormalities in children and adolescents with COVID-19
Experts from five continents publish consensus statement on chest imaging in pediatric patients with COVID-19
Though scarce, the literature on pediatric chest imaging in COVID-19 pneumonia indicates that imaging features differ between children and adults. This consensus statement therefore describes relevant manifestations, the potential use of structured reporting, and recommendations for using chest X-rays and CT images to evaluate pediatric COVID-19.
Comparing clinical and CT features of COVID-19 in pediatric and adult patients in Guangzhou, China
Early-onset infection with SARS-CoV-2 in neonates born to mothers with COVID-19 in Wuhan, China
A preliminary analysis of pregnancy and perinatal outcomes of women with COVID-19 pneumonia
Assessing radiography’s usefulness in detecting COVID-19
Researchers investigate frequency and distribution of chest X-ray findings in COVID-19 patients
Interview with the vice president of the Spanish Society of Medical Radiology (SERAM)
Milagros Martí de Gracia, vice president of SERAM and head of a Madrid radiology unit, talks about COVID-19 from the perspective of chest X-rays, CT scans, and more. Topics include protocols for dealing with confirmed and suspected patients, the importance of radiology in diagnosing infection, typical imaging findings, and her view on the situation in Spain.
How radiology departments can prepare for the postcrisis situation
While guidance on preparing for COVID-19 exists, resources for postcrisis planning are lacking. This article aims to create awareness of how the aftermath and consequences of COVID-19 might affect radiology departments. The authors address issues that will arise once hospitals begin to normalize, and offer solutions drawn from their own radiology department.
Imaging studies from SARS and MERS as lessons for radiologists in the current pandemic
This study from February 2020 reviews imaging studies of SARS and MERS patients. Since these diseases overlap with COVID-19, experiences drawn from them can help guide radiologists in the current pandemic. The authors discuss the imaging spectrum of SARS and MERS during the acute and chronic phases, and then examine imaging findings in COVID-19 patients.
COVID-19 pneumonia and the value of imaging in its diagnosis
The authors of this review note that problems with viral nucleic acid testing have led some clinicians to propose CT for diagnosing COVID-19. After discussing the etiology and epidemiology of SARS-CoV-2, the authors then describe imaging features on chest radiographs and CT scans, and assess the role of imaging in COVID-19 and for differential diagnosis.
COVID-19 will have a profound economic impact on radiology practices in the United States
Preparing to get cancer imaging back on track after COVID-19
A normal chest X-ray does not guarantee the absence of COVID-19
University of Washington shares policies and guidelines for COVID-19 preparedness
Fleischner Society publishes consensus statement on the role of chest imaging in patient management during the COVID-19 pandemic
Mass-casualty incident planning for radiology departments during the COVID-19 pandemic
Singapore radiology department draws on SARS experience to provide strategies for preventing COVID-19 spread in radiology
European Society of Radiology broadcasts experts discussing their experiences in the radiology and management of COVID-19
Ambra Health CEO says COVID-19 spotlights the need for virtual services, including teleradiology
Radiology Expert Panel Shares Policies and Procedures to Best Prepare for the COVID-19 Pandemic
Radiology-specific resources for COVID-19 collected by the American College of Radiology®
Implications for radiology management during the COVID-19 international public health emergency
A review of the literature on existing drugs that could help to treat COVID-19
The authors of this literature review identified 22 articles that reported on the effectiveness of existing drugs against COVID-19. Published between January 1 and March 25, the articles include case reports, lab tests, and animal trials. They cover four categories of drug: antiviral/anti-inflammatory, antimalarial, traditional Chinese, and others.
Outcomes of severe COVID-19 patients who received remdesivir on a compassionate-use basis
This paper describes a program sponsored by Gilead Sciences. Patients with severe COVID-19 received remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, on a compassionate-use basis. While clinical improvement occurred in over half the patients, randomized controlled trials will soon provide more informative evidence about the drug.
Evaluating the evidence for using remdesivir to treat patients with COVID-19
The authors of this paper note that treating patients with “conventional drugs in new use” has become a feasible option for COVID-19, and that remdesivir could become a “specific drug” for the disease. After examining aspects of both the virus and the disease, the paper analyzes remdesivir to establish the feasibility of conducting experiments on COVID-19.
A network-based methodology for repurposing drugs to target novel coronavirus 2019-nCoV/SARS-CoV-2
As a drug discovery strategy, drug repurposing has the potential to achieve its goal quicker and at a lower cost than de novo drug discovery. With that in mind, these researchers have developed a powerful, network-based methodology capable of rapidly identifying possible repurposable drugs and potential drug combinations for targeting SARS-CoV-2.
Unravelling the cellular factors used by SARS-CoV-2 for cell entry
This study shows that SARS-CoV-2 infection relies on host cell factors ACE2 and TMPRSS2, and that a clinically proven protease inhibitor can block it. The authors also describe how SARS-CoV antibodies could offer some protection against SARS-CoV-2. The results provide important knowledge about the new virus, and point to a target for antiviral intervention.
Narrative review of proposed pharmacologic treatments for COVID-19
This paper reviews relevant English-language articles (randomized controlled trials, case reports, case series, reviews) and active clinical trials focusing on major proposed treatments for COVID-19. It addresses selected repurposed drugs, selected investigational drugs, adjunctive therapies, and current clinical treatment experience and recommendations.
Passive immunization via monoclonal antibodies as a possible therapeutic intervention for COVID-19
Using a tried-and-tested approach for the new challenge of COVID-19
Initial clinical experience of administering convalescent plasma to critically ill COVID-19 patients in Shenzhen, China
Ivermectin, an FDA-approved drug, found to inhibit SARS-CoV-2 replication in vitro
First report on point-of-care lung ultrasound in COVID-19 pneumonia, and potential applications
Early experience with lung ultrasonography for evaluating SARS-CoV-19 infection in China
Can lung ultrasound help in the early diagnosis of COVID-19 pneumonia in critical care settings?
A simple, quantitative, and reproducible method for standardized use of lung ultrasound for COVID-19 patients
Guidelines for cleaning and preparing ultrasound transducers and equipment, and for safe handling and use of coupling gel
A practical approach to lung ultrasound in pregnant women with suspected COVID-19 infection
Chinese researchers present early experience with lung ultrasonography for evaluating COVID-19 infection
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